Burn
Conditions
Interventions
Experimental group ES group (esketamine and sufentanil):Esketamine combined with sufentanil
Control group S (sufentanil):Sufentanil alone
Sponsors
The First People’s Hospital of Lianyungang
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients >=18 years old, BMI18-30kg/m^2; 2.ASA?-? grade, patients scheduled for elective scab resection and skin grafting surgery; 3.No history of mental illness or mental illness, not pregnant or lactating women; 4.The surgical site only involves the trunk and limbs, not the head, neck and perineum. The patient has no airway or organ damage, fractures, etc. 5.No clinical manifestations such as circulatory shock and dyspnea; 6.Receiving postoperative patient-controlled intravenous analgesia (PCIA); 7.No need for ICU admission or tracheal intubation after surgery; 8.Clearly understand and voluntarily participate in this study, and sign the informed consent form;
Exclusion criteria
Exclusion criteria: 1. Allergy to the investigational drug; 2. Unstable ischemic heart disease, severe pulmonary hypertension, poorly controlled or untreated hypertension (systolic/diastolic pressure over 180/100 mmHg); 3. Risk of increased intracranial or intraocular pressure; 4. Untreated or inadequately treated hyperthyroidism or history of epilepsy; 5. Chronic pain or long-term use of analgesics; 6. Need for mechanical ventilation during the perioperative period or presence of significant organ dysfunction; 7. Requirement for multiple surgeries during the study; 8. Refusal or inability to use a patient-controlled intravenous analgesia (PCIA) pump; 9. Preoperative 1-day Patient Health Questionnaire-9 (PHQ-9) score >= 15.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative anxiety and depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative pain;Preoperative and postoperative anxiety scores;Postoperative recovery quality;Preoperative and postoperative depression scores;postoperative sleep quality; | — |
Countries
China
Contacts
Public ContactRuidong Sun
The First People’s Hospital of Lianyungang
Outcome results
None listed