Type 2 Diabetes Mellitus
Conditions
Interventions
Glucagon-like peptide-1 receptor agonist group:None
Other hypoglycemic drug groups:None
Sponsors
Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. ASA physical status II–III; 3. A confirmed diagnosis of type 2 diabetes mellitus (T2DM); 4. Scheduled to undergo elective laparoscopic sleeve gastrectomy (LSG).
Exclusion criteria
Exclusion criteria: 1. Severe cardiac, hepatic, or renal insufficiency; 2. A definite history of neuropsychiatric disorders or long-term use of central nervous system medications; 3. Preoperative Mini-Mental State Examination (MMSE) score < 24 (illiterate <= 17; primary school education <= 20); 4. Severe sensory impairment that would affect follow-up assessments; 5. Unclear medication history, uncertain duration of medication use, or inability to recall medication use; 6. History of surgery under general anesthesia within the past 3 months; 7. Participation in another clinical trial within the past 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of POD within 3 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of postoperative nausea and vomiting (PONV) within 72 hours after surgery;Pain scores within 72 hours after surgery;Postoperative sleep quality measures;Time to first postoperative flatus and first bowel movement;Inflammatory markers on postoperative day 1;Cognitive-related protein biomarkers on postoperative day 1;The incidence of POCD on postoperative day 7 or before discharge;Long-term cognitive function indicators; | — |
Countries
China
Contacts
Public ContactXiaoping Gu
Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University
Outcome results
None listed