Dentition Defect
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Sign the informed consent form. 2. Age between 13 and 64 years (inclusive). 3. Possess teeth indicated for extraction, which will serve as the source for periodontal ligament stem cells. 4. No intention to collect and retain the teeth scheduled for extraction.
Exclusion criteria
Exclusion criteria: 1. The tooth scheduled for extraction exhibits severe periodontal inflammatory infection. 2. Concurrent participation in other research studies. 3. Poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Osteogenic differentiation level of PDLSCs on day 7 following laser irradiation/control treatment;PDLSCs proliferation, migration, gene and protein expression, signaling pathway changes;Cell proliferation level detection; | — |
Countries
China
Contacts
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine