Helicobacter pylori gastritis
Conditions
Interventions
Group A:Anaprazole + Amoxicillin + Furazolidone + Colloidal Bismuth Pectin
Group B:Rabeprazole + Amoxicillin + Furazolidone + Colloidal Bismuth Pectin
Sponsors
NanJing First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18-65 years ; 2.Patients with a positive 13C or 14C breath test who have not received prior H. pylori eradication therapy; 3.Voluntary enrolment and informed consent.
Exclusion criteria
Exclusion criteria: 1.Those who are allergic to the drugs used in the eradication programme; 2.Patients with recent bleeding from gastroduodenal ulcers or signs of bleeding within the past 4 weeks; 3.Patients with a history of Helicobacter pylori eradication therapy; 4.Use of antibiotics or bismuth within 4 weeks prior to the initiation of study treatment, or use of histamine H2-receptor antagonists (H2RAs) or proton pump inhibitors (PPIs) within 2 weeks prior to the initiation of study treatment. (Note: This translation maintains the medical terminology and accurately reflects the timeframes for medication restrictions before starting the study.); 5.Use of corticosteroids, nonsteroidal anti-inflammatory drugs (NSAIDs), or anticoagulants. 6.Patients with a history of esophageal or gastric surgery; 7.Pregnant or lactating women; 8.Patients with concurrent severe physical or mental illnesses, or hepatic/renal dysfunction; 9.Patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma or malignant tumors. 10.Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency, peptic ulcer disease, or bronchial asthma. 11.Has the following comorbid medications: atazanavir or rilpivirine, tricyclic antidepressants, levodopa, acetaminophen, guaifenesin/dextromethorphan, monoamine oxidase inhibitors, tramadol, and others.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse reactions;Patient compliance; | — |
Countries
China
Contacts
Public ContactZhang Zhenyu
NanJing First Hospital
Outcome results
None listed