Cognitive Impairment
Conditions
Interventions
Experimental Group:Administer a loading dose of 1.0 mg/kg lidocaine first, then maintain continuous intravenous infusion of 1.0 mg/kg lidocaine till surgery completion.
Control group:Administer equal doses of normal saline infusion
Sponsors
Shihezi People's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Elderly patients (of either gender) scheduled for elective UBE surgery; 2. Age range: 60 - 85 years old; 3. BMI: 18 - 28 kg/m^2; 4. ASA I-II grade; 5. Education level: primary school or above; 6. No obvious heart or lung diseases, normal communication skills; 7. Voluntary and willing to sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Severe heart, liver or kidney diseases; 2. Long-term use of opioid drugs; 3. Allergy or contraindication to lidocaine; 4. Anxiety and/or depression; 5. Surgical death, massive bleeding during surgery, requiring blood transfusion, and needing to be transferred to the intensive care unit for further treatment after surgery; 6. Those with unclear ultrasound temporal window imaging.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive level assessment results; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic indicators;Surgical-related indicators; | — |
Countries
China
Contacts
Public ContactXiuling Wu
Shihezi People's Hospital
Outcome results
None listed