Leiomyoma
Conditions
Interventions
Oxycodone group:Patients in the oxycodone group received an intravenous loading dose of oxycodone (2 mg) at the time of abdominal closure, followed by connection to a patient-controlled intravenous an
Sufentanil Group:Patients in the sufentanil group received an intravenous loading dose of sufentanil (3 µg) at the time of abdominal closure, followed by connection to a PCIA pump after surgery. The P
Sponsors
The First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 - 65 years old; 2. BMI: 18 - 28 kg/m^2; 3. Weight: 50 - 70 kg 4. ASA classification: I - III grade; 5. Planned to undergo laparoscopic myomectomy of the uterus; 6. No use of analgesic drugs within 24 hours before the operation.
Exclusion criteria
Exclusion criteria: 1. Refuse to participate in this study; 2. Have mental disorders; 3. Have been using opioid drugs and other analgesic drugs for a long time; 4. Had chronic pain before the surgery; 5. Have severe dysfunction of heart, lung, liver or kidney: Heart function: NYHA classification at grade III or IV; Liver function: Child-Pugh classification at grade B or C, or ALT/AST higher than the upper limit of normal value by more than twice; Kidney function: Serum creatinine (Cr) level higher than the upper limit of normal value by 1.5 times, or estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m^2; Respiratory function: Have severe chronic obstructive pulmonary disease or blood oxygen saturation (SpO2) < 92% at rest. 6. Pregnant or lactating women; 7. Have language disorders or expression disorders; 8. Patients with contraindications to oxycodone or sufentanil.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of moderate-to-severe visceral pain at rest within 48 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of moderate-to-severe incisional pain within 48 hours after surgery;Incidence of moderate-to-severe low back pain within 48 hours after surgery;Incidence of moderate-to-severe shoulder pain within 48 hours after surgery;NRS scores of different types of pain at rest at 24 hours postoperatively;NRS scores of pain during movement at 24 hours postoperatively;NRS scores of different types of pain at rest at 48 hours postoperatively;NRS scores of pain during movement at 48 hours postoperatively;Number of patient-controlled intravenous analgesia (PCIA) demands within 48 hours after surgery;Time to first PCIA demand after surgery;Total analgesic consumption within 48 hours after surgery;Use of rescue analgesic medications within 48 hours after surgery;Quality of Recovery-15 (QoR-15) score at 24 hours after surgery;Quality of Recovery-15 (QoR-15) score at 48 hours after surgery;Patient satisfaction with postoperative analgesia assessed using a Likert scale at 48 hours postoperatively;Highest Numerical Rating Scale (NRS) pain score during the post-anesthesia care unit (PACU) stay; | — |
Countries
China
Contacts
Public ContactHuang Luping
The First Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed