Postoperative Pulmonary Complications (PPCs)
Conditions
Interventions
Intravenous Anesthesia Group:Patients in the Intravenous Anesthesia Group received total intravenous anesthesia (TIVA) according to surgical requirements. Specifically, propofol was administered at an
Inhalational Anesthesia Group:Patients in the Inhalational Anesthesia Group received inhalational anesthesia according to surgical requirements, using sevoflurane maintained at an inhaled concentratio
Sponsors
Nanfang Hospital, Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Voluntarily signed informed consent form. 2. Adult patients aged 18-85 years. 3. Patients diagnosed with benign tumors, pulmonary fibrosis, bronchiectasis, congenital lung diseases, severe chronic obstructive pulmonary disease (COPD), lung injury due to trauma, or chronic pulmonary embolism. 4. Scheduled to undergo elective pulmonary resection surgery under general anesthesia, with an anticipated one-lung ventilation duration exceeding 1 hour. 5. ASA physical status classification of I to III.
Exclusion criteria
Exclusion criteria: 1. History of acute lung injury prior to surgery. 2. Experience of ARDS or respiratory failure within the last three months. 3. Presence of major illnesses such as severe hepatic dysfunction (e.g., liver failure or Child-Pugh class B or C). 4. Chronic renal impairment with GFR < 30 ml/min. 5. History of severe heart failure, classified above NYHA class 2. 6. History of inadequately controlled asthma, or FEV1% < 60%. 7. After enrollment, the investigator will record required study information (including age, gender, height, weight, relevant medical history, and medication history) for experimental purposes. Subjects deemed unsuitable for participation by the investigator based on this information will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to extubation;Oxygenation index (OI) at different perioperative time points;The incidence of postoperative pulmonary complications (PPCs) within the first week after surgery;Chest X-ray and routine laboratory tests; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of post-extubation pulmonary complications (PEPCs) within the first week after surgery;The incidence of pulmonary complications within the postoperative period of days 7 to 30;Length of stay in the intensive care unit/intermediate care unit and time to discharge.;Major in-hospital cardiac or cerebrovascular events and acute renal failure;Cardiac tissue and plasma/urine biomarkers; | — |
Countries
China
Contacts
Public ContactLiu Kexuan
Nanfang Hospital, Southern Medical University
Outcome results
None listed