Major Depressive Disorder
Conditions
Interventions
Intervention Group A:Left lateral prefrontal cortex stimulation sequence: 2-second burst stimulation (each sequence consists of 10 double pulses, with a pulse frequency of 50 Hz and delivered at a rat
Intervention Group B:Simple left lateral prefrontal cortex stimulation sequence: High-frequency 10Hz stimulation, a total of 1800 pulses + medication.
Control group:Except for the group that did not receive transcranial magnetic stimulation treatment, all others were the same as the intervention group.
Sponsors
The First Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
13 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1? Inpatients who meet the diagnostic criteria for major depressive disorder according to the DSM-5 and are confirmed by the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI Kid). 2? Age range between 13 to 18 years old, no gender restrictions. 3?The use of medications is based on clinical practice guidelines (CPGs) and other evidence-based medical references, selecting drugs that are safe and can be used within therapeutic dosages for adolescents. 4?Signed by the patient's legal guardian on the informed consent form. 5?Over 5 years of educational experience, normal intelligence, comprehension ability sufficient to cooperate in completing scale assessments, near-infrared brain function imaging examination.
Exclusion criteria
Exclusion criteria: 1?Patients with acute cerebral hemorrhage and acute infectious diseases; 2?History of epilepsy and family history. 3?Patients with depression who have strong suicidal tendencies or agitation and cannot cooperate with magnetic stimulation therapy and near-infrared brain function imaging examination; 4?Patients with severe headaches, hypertension, malignant tumors, open wounds, vascular embolism, leukopenia, and other conditions. 5?Inability to remove metallic objects contained within the body.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Near-infrared brain functional imaging technology; | — |
Secondary
| Measure | Time frame |
|---|---|
| Montgomery-?sberg Depression Scale score;Hamilton Anxiety Scale score; | — |
Countries
China
Contacts
Public ContactGao Minglong
The First Hospital of Hebei Medical University
Outcome results
None listed