Obstructive sleep apnea (OSA)
Conditions
Interventions
Control group:None
Sponsors
Affiliated Hospital of Southwest Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age > 18 years old, gender not limited; 2.OSA Group (Group 1): Diagnosed with moderate to severe OSA via polysomnography, with an apnea-hypopnea index (AHI) >=15 times/hour (moderate: 15-30 times/hour; severe: >30 times/hour). 3.Control group (Group 2): No OSA (AHI < 5 times/hour), matched with the OSA group for age (± 3 4 5 years) and sex. 4.Both groups must meet the following requirements: no continuous positive airway pressure (CPAP) therapy for at least 3 days prior to the assessment; and voluntarily participate and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with malignant tumors or receiving related treatment; 2. Current use of ß-blockers (may affect catecholamine detection); 3. patients with phenylketonuria (PKU); 4. Patients with severe chronic liver/kidney disease and heart failure (New York Heart function class ?-?); 5. Pregnant or lactating women; 6. Other conditions that the investigator considers may affect the study results (e.g., mental illness inability to cooperate with the examination). (Use a checklist to make a list of conditions that could affect the efficacy or safety assessment of the study, such as other treatments contrary to the inclusion criteria, coexisting conditions, and pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in core serum biomarkers (NT-proBNP, hs-TnI, fasting glucose, lipid profile, insulin, cortisol/aldosterone, catecholamines, liver/kidney function markers) between OSA and control groups; | — |
Countries
China
Contacts
Public ContactTian Gang
Affiliated Hospital of Southwest Medical University
Outcome results
None listed