Quality of postoperative recovery in patients undergoing gastrointestinal tumor surgery
Conditions
Interventions
Group A:Anesthesia induction: Anesthesia induction in group A was induced by intravenous injection of phosphopropofenol disodium 10~20mg/kg, sufentanil 0.3µg/kg, and cis-atracurium 0.2mg/kg. Group A w
Group B:The control group did not use phosphoropofol disodium intraoperatively or in the analgesic pump
Sponsors
The Fourth Affiliated Hospital of Southwest Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Age: >=65 years old, gender is not limited; (2) ASA grade II-III; (3) Laparoscopic gastrointestinal tumor surgery is proposed, with a duration of 2~4 hours; (4) BMI:18~30kg/m^2; (5) No history of drug allergy; (6) Voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Severe cardiovascular and cerebrovascular diseases (such as NYHA grade >= III or LVEF =160/100 mmHg); acute coronary syndrome or stroke within 6 months); (2) Abnormal liver and kidney function (ALT/AST> 2-fold upper limit, eGFR7.5%); (4) History of neurological or psychiatric diseases; (5) Allergy to propofol or soy/egg; (6) Intraoperative blood loss greater than 15ml/kg or intraoperative blood transfusion (7) Those with broken or infected skin in the BIS monitoring area; (8) Admitted to the ICU after surgery; (9) Patients who are deemed inappropriate by the investigator to participate in this trial or the patient refuses to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The QoR 15 scores of the two groups were recorded at 1 day before, 1 day and 3 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| MAP, heart rate, and SpO2 5 minutes before anesthesia induction (T0), 1 minute after induction (T1), 1 minute after endotracheal intubation (T2), immediately after skin incision (T3) and immediately after endotracheal extubation (T4).;Duration of anesthesia (time from the start of anesthesia to the discontinuation of intravenous anesthetic infusion), operative time, intraoperative fluid volume, blood loss, urine output, use of anesthetic and vasoactive drugs, hypotension (MAP decrease >20% of basal value, duration =120s), and bradycardia (heart rate <50 beats/min).;Time to awakening (time from discontinuation of intravenous anesthetic infusion to awakening), time to extubation (time from discontinuation of intravenous anesthetic infusion to endotracheal extubation), length of stay in the anesthesia recovery unit (PACU) and length of hospital stay after surgery;Restlessness score (RS) score and Ramsay sedation score upon awakening; | — |
Countries
China
Contacts
Public ContactJian zhan
The Fourth Affiliated Hospital of Southwest Medical University
Outcome results
None listed