Skip to content

A prospective randomized controlled study on the efficacy of bupivacaine liposome rectus abdominis sheath block and transversus abdominis plane block in postoperative analgesia and recovery quality in women undergoing cesarean section

A prospective randomized controlled study on the efficacy of bupivacaine liposome rectus abdominis sheath block and transversus abdominis plane block in postoperative analgesia and recovery quality in women undergoing cesarean section

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600117163
Enrollment
Unknown
Registered
2026-01-20
Start date
2026-02-01
Completion date
Unknown
Last updated
2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postpartum pain

Interventions

Rectus abdominis placebo control group:The specific procedure for rectus abdominis sheath block is as follows: Under ultrasound guidance, a needle is inserted at the lateral edge of the rectus abdomin
Rectus sheath block group:The specific procedure for rectus abdominis sheath block is as follows: Under ultrasound guidance, a needle is inserted at the lateral edge of the rectus abdominis muscle. Th
transversus abdominis fascia placebo control group:Specific method for transversus abdominis plane nerve block: Position the ultrasound probe axially at the midline, two finger-widths below the umbili

Sponsors

Third Xiangya Hospital, Central South University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 55 Years

Inclusion criteria

Inclusion criteria: (1) Age >= 18 years and = 50 kg (5) No history of allergy to local anesthetics or contraindications (6) Capable of self-assessing pain and able to answer NRS scores after training (7) Possesses normal communication skills; voluntarily participates and signs the informed consent form

Exclusion criteria

Exclusion criteria: (1) Patients with known allergies to bupivacaine or other substances, or those with an allergic constitution (allergic to two or more drugs, environmental factors, or foods), or those prone to rashes, urticaria, etc., or those with a history of allergic diseases; (2) Patients with contraindications to non-steroidal anti-inflammatory drugs (NSAIDs): allergy to NSAIDs; active bleeding disorders such as gastrointestinal ulcers or perforations within the past 6 months; (3) Patients with a history of local anesthetic toxicity; (4) Patients with contraindications to subarachnoid block; (5) Patients with severe infections; (6) Patients with intraoperative blood loss >800 ml or those requiring vasoactive drugs to maintain hemodynamic stability postoperatively; (7) Patients with severe arrhythmias on electrocardiogram or cardiac monitoring (such as frequent premature ventricular contractions, second-degree type II or third-degree atrioventricular block, atrial fibrillation, etc.), deemed unsuitable for inclusion by the investigator; (8) Patients with central nervous system diseases (Parkinson's disease, Alzheimer's disease, essential tremor, hepatolenticular degeneration, Huntington's disease, epilepsy, etc.), mental disorders (schizophrenia, mania, anxiety disorder, bipolar disorder, psychosis, etc.), cognitive impairment, head injury, possible intracranial hypertension, cerebral aneurysm, or a history of cerebrovascular accident; (9) Skin infection at the puncture site; (10) Patients deemed unsuitable by the investigator.

Design outcomes

Primary

MeasureTime frame
Total sufentanil dose in the first 24 hours post-surgery (PCIA + rescue analgesia);

Secondary

MeasureTime frame
Area under the curve of incision pain intensity-time in the mother at rest for 0-48 hours after surgery;Sufentanil salvage doses 24h and 48h postpartum;Area under the curve of incision pain intensity-time during active state in postpartum women 0-48 hours after surgery;Pain scores at rest and during activity (deep breathing) after nerve block.;Total sufentanil dose 48 hours post-surgery;Postpartum recovery quality score 24 hours after delivery;Sufentanil salvage doses 24h and 48h postpartum;

Countries

China

Contacts

Public ContactSaiying Wang

Third Xiangya Hospital, Central South University

16420634422@qq.com+86 158 7485 8486

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026