Postpartum pain
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: (1) Age >= 18 years and = 50 kg (5) No history of allergy to local anesthetics or contraindications (6) Capable of self-assessing pain and able to answer NRS scores after training (7) Possesses normal communication skills; voluntarily participates and signs the informed consent form
Exclusion criteria
Exclusion criteria: (1) Patients with known allergies to bupivacaine or other substances, or those with an allergic constitution (allergic to two or more drugs, environmental factors, or foods), or those prone to rashes, urticaria, etc., or those with a history of allergic diseases; (2) Patients with contraindications to non-steroidal anti-inflammatory drugs (NSAIDs): allergy to NSAIDs; active bleeding disorders such as gastrointestinal ulcers or perforations within the past 6 months; (3) Patients with a history of local anesthetic toxicity; (4) Patients with contraindications to subarachnoid block; (5) Patients with severe infections; (6) Patients with intraoperative blood loss >800 ml or those requiring vasoactive drugs to maintain hemodynamic stability postoperatively; (7) Patients with severe arrhythmias on electrocardiogram or cardiac monitoring (such as frequent premature ventricular contractions, second-degree type II or third-degree atrioventricular block, atrial fibrillation, etc.), deemed unsuitable for inclusion by the investigator; (8) Patients with central nervous system diseases (Parkinson's disease, Alzheimer's disease, essential tremor, hepatolenticular degeneration, Huntington's disease, epilepsy, etc.), mental disorders (schizophrenia, mania, anxiety disorder, bipolar disorder, psychosis, etc.), cognitive impairment, head injury, possible intracranial hypertension, cerebral aneurysm, or a history of cerebrovascular accident; (9) Skin infection at the puncture site; (10) Patients deemed unsuitable by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total sufentanil dose in the first 24 hours post-surgery (PCIA + rescue analgesia); | — |
Secondary
| Measure | Time frame |
|---|---|
| Area under the curve of incision pain intensity-time in the mother at rest for 0-48 hours after surgery;Sufentanil salvage doses 24h and 48h postpartum;Area under the curve of incision pain intensity-time during active state in postpartum women 0-48 hours after surgery;Pain scores at rest and during activity (deep breathing) after nerve block.;Total sufentanil dose 48 hours post-surgery;Postpartum recovery quality score 24 hours after delivery;Sufentanil salvage doses 24h and 48h postpartum; | — |
Countries
China
Contacts
Third Xiangya Hospital, Central South University