Hepatocellular Carcinoma
Conditions
Interventions
Experimental group:68Ga-DOTA-CTC1 and 18F-FDG PET-CT imaging
Sponsors
Tianjin Medical University Cancer Institute and Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 18 to 75 years (including both age limits); 2. Legally competent individuals who voluntarily participate in this clinical study and sign an Informed Consent Form (ICF); 3. Patients with suspected hepatocellular carcinoma based on contrast-enhanced CT or MR imaging; 4. Patients scheduled for surgery or pathological examination within 60 days after imaging, who agree to provide sufficient and suitable tumor tissue samples (formalin-fixed, paraffin-embedded specimens) postoperatively for pathological testing at the research center; 5. Have not received any of the following treatments for this tumor: tumor resection/curative surgery (excluding diagnostic biopsy), radiotherapy (including brachytherapy), systemic anticancer drugs (chemotherapy, small-molecule targeted agents, monoclonal antibodies, etc.), or experimental treatments in other clinical studies.
Exclusion criteria
Exclusion criteria: 1. Patients with other clearly diagnosed malignant tumors; 2. Patients with uncontrolled severe infections or concomitant serious illnesses; 3. Patients with an expected survival period <= 3 months; 4. Pregnant or lactating patients, and patients of childbearing potential who refuse to use appropriate contraceptive measures during this trial; 5. Patients deemed unsuitable for participation in this study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Medication Safety;Radiation Absorption Dose Characteristics;Biodistribution Profile;PET Imaging Characteristics; | — |
Secondary
| Measure | Time frame |
|---|---|
| The correlation between PET imaging and GPC3 expression levels as measured by immunohistochemistry (IHC);Diagnostic Efficacy; | — |
Countries
China
Contacts
Public ContactDai Dong
Tianjin Medical University Cancer Institute and Hospital
Outcome results
None listed