Organ dysfunction
Conditions
Interventions
Group with abnormal capillary refill time, a blood pressure response index less than or equal to 7, and mean arterial pressure (MAP) of 65-75 mmHg:NA
Normal capillary refill time group:NA
Group with abnormal capillary refill time, blood pressure response index greater than 7, and mean arterial pressure of 76–85 mmHg:NA
Sponsors
Southern Medical University Southern Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Voluntarily sign the informed consent form; 2. Age >=18 years; 3. ICU patients with septic shock.
Exclusion criteria
Exclusion criteria: 1. Patients diagnosed with septic shock for more than 6 hours; 2. Patients for whom accurate CRT measurement is not possible (including severe limb defects, local infections at the measurement site, Fitzpatrick skin types V-VI, history of Raynaud's phenomenon, etc.); 3. Patients on ECMO support; 4. Patients expected to undergo surgery or dialysis during the 6-hour intervention period; 5. Patients who have had a myocardial infarction within the past three months or have recently (within 30 days) undergone major cardiac or neurosurgery; 6. Post-cardiopulmonary resuscitation patients; 7. Patients with progressive acute coronary syndrome; NYHA class IV heart function or refractory heart failure; 8. Patients with cardiogenic or predominantly cardiogenic mixed shock; 9. Patients with other conditions requiring more stringent blood pressure control (such as uncontrolled active bleeding, aortic dissection, acute stroke, etc.); 10. Patients with acute hematologic malignancies; 11. Patients with care limitations such as a decision to forgo aggressive treatment; 12. Pregnant or breastfeeding patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Absolute change in capillary refill time; | — |
Secondary
| Measure | Time frame |
|---|---|
| ScvO?;Pv-aCO? ; | — |
Countries
China
Contacts
Public ContactShumin Cai
Southern Medical University Southern Hospital
Outcome results
None listed