Knee arthritis
Conditions
Interventions
The experimental group (ACB group):30 minutes before the operation, the anesthesiologist performed a bupivacaine liposome 133mg femoral nerve block for pain relief under color ultrasound guidance.
Control group (PAI group):At the end of the surgery, the surgeon administered a 133mg injection of bupivacaine liposome around the joint to provide pain relief before closing the joint cavity.
Sponsors
Chengdu Second People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 - 75 years old, gender not restricted; 2. Meets the indications for unilateral total knee arthroplasty (primary or secondary osteoarthritis, rheumatoid arthritis, etc.), and has American Society of Anesthesiologists (ASA) classification of grade I - III; 3. Preoperative knee joint range of motion (Range of Motion, ROM) >= 90°, Visual Analogue Scale (VAS) pain score <= 3 points (resting state); 4. Can understand and cooperate to complete pain assessment, functional evaluation and follow-up procedures; 5. Voluntarily sign the informed consent form, and has no contraindications related to the trial.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic to bupivacaine, liposome carriers or the drug components injected around the joint (such as ropivacaine, epinephrine, glucocorticoids, etc.); 2. Those with coagulation dysfunction (prothrombin time > 1.2 times the upper limit of normal, activated partial thromboplastin time > 1.5 times the upper limit of normal, platelet count 2 times the upper limit of normal; kidney function: serum creatinine > 133µmol/L (male), > 106µmol/L (female)); 5. Those with neurological diseases (such as peripheral neuropathy, spinal cord injury, history of epilepsy, etc.) or mental disorders (such as depression, schizophrenia) that affect pain perception and functional assessment; 6. Those who have a history of knee joint surgery, severe trauma or are participating in other clinical trials within 6 months before the operation; 7. Pregnant or lactating women; 8. Those with a history of opioid abuse or dependence; 9. Those who are expected to be unable to cooperate with early rehabilitation training after the operation (such as due to severe cardiovascular diseases, cognitive impairments, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| The consumption of opioid drugs;The incidence rate of adverse reactions related to pain relief;Knee joint function recovery;Length of hospital stay;Overall satisfaction; | — |
Countries
China
Contacts
Public ContactMan Yang
Chengdu Second People’s Hospital
Outcome results
None listed