Alzheimers disease
Conditions
Interventions
Transcranial time-domain interference electrical stimulation (tTIS) group:Transcranial time-domain interference electrical stimulation
Sponsors
The First Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Meets the NIA-AA (2018) published AD diagnosis criteria; 2.Ages between 60-80, gender not specified; 3.Clinical Dementia Rating Scale (CDR) initial screening score of 0.5 or 1; 4.The patients can communicate normally and complete the scales involved in the study independently. 5.Biomarker positive; 6.Voluntarily participate in the research with full understanding of the research content, process, and potential risks, and jointly sign the written informed consent approved by the ethics with the guardian;
Exclusion criteria
Exclusion criteria: 1.Merged with other neurological, psychiatric, or brain diseases, etc; 2.History of previous brain surgery; 3.Patients with epilepsy, severe cognitive dysfunction and inability to cooperate; 4.Those with a history of psychosis or communication disorders; 5.Contraindications to MRI or tTIS, such as metal implants, pacemakers, claustrophobia, and incomplete skull; 6.Investigators who have participated in other clinical trials;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog); | — |
Secondary
| Measure | Time frame |
|---|---|
| Instrumental activities of daily living;Neuroimaging evaluation of near-infrared non-invasive cerebral function detection;Montreal Cognitive Assessment;Incidence of adverse events;Mini-Mental State Examination;Neuropsychiatric symptom questionnaire;Self-care ability assessment in daily life; | — |
Countries
China
Contacts
Public ContactJingming Hou
The First Affiliated Hospital of Army Medical University
Outcome results
None listed