Traumatic optic neuropathy
Conditions
Interventions
Experimental group:Perform routine optic canal decompression surgery and implant bFGF bio-release material at the lesion site
Control Group:Perform routine optic canal decompression surgery and transplant biodegradable gelatin blank materials at the lesion site
Sponsors
Wenzhou Medical University Affiliated Ophthalmology Hospital
Eligibility
Sex/Gender
All
Age
8 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed as TON (either single eye or both eyes can be included); 2. Within 3 months after injury; 3. Age ranging from 8 years to 65 years; 4. Corrected visual acuity ranging from light perception to 0.1; 5. Within 2 weeks after injury, no improvement in vision was observed after 3 days of hormone shock treatment (methylprednisolone 1000 mg/day); 6. The patient was conscious, expressed fluently, voluntarily participated in this study, and personally signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Combined with retinal and optic nerve avulsion injuries; 2. Preoperative CTA vascular scan revealed definite or suspected abnormalities of the internal carotid artery or ophthalmic artery; 3. There are surgical contraindications, and preoperative examination indicated chronic infection in the paranasal sinuses; 4. Suffer from other ocular diseases (including vitreous hemorrhage, glaucoma, high myopia); 5. Lens opacity; 6. History of diabetes; 7. Lack of capacity for informed consent or restricted informed consent; 8. Lack of civil capacity or restricted civil capacity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Best spectacle-corrected visual acuity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Flash visual evoked potential;Peripapillary vessel density;Peripapillary RNFL thickness;Temperature;Pattern visual evoked potential;Graphic electroretinogram;Pupillary light response;Optic nerve head optical coherence tomography circle scans;Cranial computed tomography ;Slit lamp examination;Fundus photography;Visual field measurement;Respiration rate;Blood pressure;Heart rate;Mental state;Consciousness assessment; | — |
Countries
China
Contacts
Public ContactWu Wencan
Wenzhou Medical University Affiliated Ophthalmology Hospital
Outcome results
None listed