thrombophilia
Conditions
Interventions
Thrombophilia Pregnant Women Group:None
Sponsors
The Second Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
Female
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria for the Thrombophilia Group: 1. Pregnant women aged 18–45 years; 2. Meeting diagnostic criteria for hereditary or acquired thrombophilia as outlined in the Chinese Guidelines for Diagnosis and Prevention of Thrombophilia (2021 Edition) (e.g., persistent positive antiphospholipid antibodies, protein C/S deficiency, antithrombin deficiency, specific gene mutations, etc.); 3. Single gestation; 4. Informed consent provided and willingness to complete all examinations and follow-up procedures required for this study. Healthy Pregnant Women Group Inclusion Criteria: 1. Healthy pregnant women with gestational age matching that of the case group; 2. No known history of thrombophilia or laboratory evidence thereof; 3. Absence of comorbidities potentially affecting cardiovascular function, such as autoimmune diseases, chronic hypertension, diabetes mellitus, or renal disease; 4. No long-term medication use that may impact coagulation or cardiovascular function (e.g., corticosteroids, immunosuppressants).
Exclusion criteria
Exclusion criteria: 1. Severe concomitant non-cardiovascular conditions (such as active infections, malignant tumours, or severe hepatic or renal insufficiency); 2. History of smoking, alcohol consumption, or use of medications significantly impacting pregnancy outcomes; 3. Incomplete clinical data, suboptimal ultrasound image quality, or other factors precluding effective analysis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic criteria for thrombophilia (antiphospholipid antibodies, protein C, protein S, homocysteine, etc.);Blood biomarkers (blood glucose, blood lipids, placental growth factor (PlGF), folic acid, vitamin D, hCG, etc.);Metabolomics (serum, urine, and placental tissue);Multimodal ultrasound imaging (placental perfusion assessment, maternal cardiac and carotid ultrasound examinations, foetal cardiac ultrasound examinations, foetal organ perfusion assessments, uterine artery studies, routine antenatal ultrasound measurements, etc.);General Clinical Data (Blood Pressure, BMI, etc.); | — |
Countries
China
Contacts
Public ContactHongxia Yu
The Second Affiliated Hospital of Zhengzhou University
Outcome results
None listed