Respiratory failure
Conditions
Interventions
Observation group (mechanically ventilated patients):None
Sponsors
The First Affiliated Hospital, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >=18 years; 2.Patients undergoing mechanical ventilation in the ICU; 3.Length of ICU stay >= 24 hours; 4.Continuous sedation with propofol/ciprofol for >=24 hours.
Exclusion criteria
Exclusion criteria: 1.Incomplete clinical data; 2.Patients not assessed for sedation and analgesia; 3.Initiation of the study drug more than 72 hours after intubation; 4.Patients requiring deep sedation to facilitate specific therapies (e.g., prone positioning ventilation, neuromuscular blocking agents); 5.Patients unable to cooperate with RASS (Richmond Agitation-Sedation Scale) or CPOT (Critical Care Pain Observation Tool) assessments due to conditions such as traumatic brain injury or cerebrovascular disease; 6.Duration of drug administration < 24 hours; 7.Concomitant use of other sedative drugs during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation success rate;Vital Signs;Vasoactive drug;Analgesic medication; | — |
Countries
China
Contacts
Public ContactLiu Yongjun
The First Affiliated Hospital, Sun Yat-Sen University
Outcome results
None listed