Intraoperative Hypotension
Conditions
Interventions
Intervention Group:In the intervention group, hemodynamic management will be based on hemodynamic parameters provided by the Pulsioflex platform with ProAQT sensors, including cardiac index (CI) and s
Control group:The control group underwent conventional monitoring, with anesthesiologists adjusting hemodynamics based solely on central venous pressure (CVP), blood pressure (mean arterial pressure <
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Signed informed consent form with date 2. Commit to abide by the research procedures and cooperate throughout the entire research process 3. ASA: Grades I - III 4. No severe liver, kidney, heart or endocrine diseases 5. Age 18 - 80 years old 6. Gender not limited; clear consciousness, no mental illness 7. Undergoing elective pancreatic surgery under general anesthesia; estimated operation time > 2 hours.
Exclusion criteria
Exclusion criteria: 1. Individuals meeting any of the following criteria will be excluded from this study: 2. Age < 18 years old; 3. Preoperative hemodynamic instability; 4. Severe cardiac insufficiency or history of heart failure, severe cardiac shunt disease, severe aortic valve stenosis or history of severe arrhythmia; 5. Long-term history of hypotension before surgery (MAP < 65 mmHg); 6. Patients with contraindications for arterial catheterization; 7. Allergic to the study intervention; 8. Patients with coagulation dysfunction. 9. The researchers consider that there are other reasons preventing the inclusion of this subject.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time-weighted average duration of hypotension (MAP < 65 mmHg) during surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of hypotension (number of hypotensive events per patient);Total duration of hypotension and percentage of total operating time;Cumulative dose of opioids;Cumulative dose of vasoactive drugs;Cumulative dose of inotropes;Time-weighted average of tissue oxygen saturation (StO2) measurements;Length of hospitalization, postoperative complications (cardiac events, liver and kidney function, bile-enteric fistula, stroke, etc.), readmission within 30 days, and whether there are serious comprehensive outcomes (hospital death and in-hospital stroke); | — |
Countries
China
Contacts
Public ContactLuo Yan
Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed