Post-spinal anesthesia hypotension
Conditions
Interventions
Dexamethasone Group:Prophylactic administration of dexamethasone
Dexamethasone plus Ondansetron Group:Prophylactic administration of dexamethasone and ondansetron
Control group:Prophylactic administration of normal saline
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Undergoing elective cesarean section under combined spinal-epidural anesthesia; 2. Age range: 18 - 45 years old; 3. Singleton full-term pregnancy; 4. ASA (American Society of Anesthesiologists) health status classification: II - III.
Exclusion criteria
Exclusion criteria: 1. Those with a history of chronic severe hypertension or gestational hypertension or those with poor blood pressure control; 2. Those who cannot undergo intraspinal anesthesia due to contraindications; 3. Those with abnormal fetal development; 4. Those who are known to be allergic to ephedrine, dexamethasone or ondansetron; 5. Those who refuse to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Spinal Anesthesia-induced Hypotension (SAIH); | — |
Secondary
| Measure | Time frame |
|---|---|
| Frequency and total dosage of norepinephrine administration;Time interval from intrathecal injection of ropivacaine to fetal delivery;Incidence of hypotension, reactive hypertension, nausea and vomiting, and bradycardia;Changes in hemodynamic parameters (SBP, HR, CO, CI, SV, SVV, SVR);Apgar scores of neonates at 1 minute, 5 minutes, and 10 minutes;Umbilical artery blood gas analysis immediately after fetal delivery; | — |
Countries
China
Contacts
Public ContactXu Guanghong;Chen Xixi
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed