schizophrenia
Conditions
Interventions
Research Group:Atypical antipsychotic drugs + oral folic acid, 15mg per day, for 24 weeks of treatment
control group:Monotherapy with Atypical antipsychotic drugs for 12 weeks
then Atypical antipsychotic drugs + oral folic acid, 15mg per day, for 12 weeks
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Inpatients with schizophrenia who have met the ICD-10 diagnostic criteria and whose first episode or recurrence occurred within the past 3 months and who have not received antipsychotic medication treatment; 2. Age 18-60 years old, gender not limited; 3. Folate 179 pmol/ml); 4. Education level of junior high school or above, able to understand and cooperate with the C-BCT examination; 5.No continuous use of antibiotics for more than 3 days in the past 3 months; 6. 17.5 <= Body Mass Index (BMI) <= 30; 7. Good family support, able to understand and comply with the research requirements; 8. Regular diet, without special dietary habits.
Exclusion criteria
Exclusion criteria: 1. Patients with organic brain diseases, mental retardation, digestive tract diseases, pernicious anemia, epilepsy, and severe systemic diseases are excluded; (Liver function abnormality: Aspartate aminotransferase (AST) >= 2×ULN (normal upper limit); or Alanine aminotransferase (ALT) >= 2×ULN; Renal function abnormality: Creatinine (Cr) >= 1.5×ULN; Blood sugar abnormality: Fasting blood glucose >= 7.0 mmol/L; Lipid abnormality: Fasting total cholesterol > 5.5 mmol/L, or fasting triglycerides > 1.6 mmol/L) 2. Patients with substance abuse or dependence as diagnosed according to ICD-10 criteria and not completely relieved are excluded. The patient's condition is judged to meet the criteria for substance abuse or dependence as diagnosed by ICD-10 based on the medical history.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Chinese simplified version of the Neurocognitive Assessment Battery(C-BCT);Positive and Negative Syndrome Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| folic acid;Vitamin B12;Homocysteine;Inflammatory factors;Oxidative stress-related indicators; | — |
Countries
China
Contacts
Public ContactGuo Liyang
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed