Obesity and related metabolic diseases
Conditions
Interventions
Experimental Group:Low-pressure pneumoperitoneum (8 mmHg) combined with deep neuromuscular block (target TOF=0, PTC=1-2)
Control Group:Standard-pressure pneumoperitoneum (13 mmHg) combined with moderate neuromuscular block (target TOF count 1-3)
Sponsors
The Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
16 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Patients who present to the Bariatric Center from 2026 to 2028, meet the indications for metabolic surgery, and are scheduled to undergo laparoscopic sleeve gastrectomy. (2) Body mass index (BMI) between 27.5 kg/m² and 45 kg/m², inclusive. (3) Age between 16 and 70 years, inclusive.
Exclusion criteria
Exclusion criteria: (1)Patients with BMI >45 kg/m² or BMI 40) requiring non-invasive ventilation or oxygen therapy before surgery. (10) Patients who actively decline to participate in the trial. (11) Patients using medications known to interact with rocuronium preoperatively (including aminoglycosides, lincosamides, polypeptides, acylaminopenicillins, tetracyclines, metronidazole, phenytoin and carbamazepine, diuretics, monoamine oxidase inhibitors, calcium channel blockers, magnesium agents). (12) Patients lost to follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Index of Nausea, Vomiting, and Retching (INVR) score on postoperative day; | — |
Secondary
| Measure | Time frame |
|---|---|
| Operative time;Postoperative quality of recovery (Quality of Recovery-40, QoR-40 score);Postoperative pain score (Visual Analogue Scale, VAS);Postoperative serum inflammatory markers (C-reactive protein, CRP; Interleukin-6, IL-6);Postoperative complications (Clavien-Dindo classification);Nausea and vomiting score on postoperative day 3 (INVR score on POD3); | — |
Countries
China
Contacts
Public ContactPurun Lei
The Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed