Knee osteoarthritis
Conditions
Interventions
Knee Osteoarthritis Observation Group:None
Sponsors
Zhujiang Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 45 and 79 years; 2. Experiencing knee pain; 3. Possessing basic reading and writing skills and willing to participate in the study.
Exclusion criteria
Exclusion criteria: 1. Participants with severe knee OA requiring joint replacement surgery within the next 6 months; 2. Individuals with contraindications to MRI, such as those with a pacemaker, artificial metallic valves or corneas, history of aneurysm clipping, intraocular metallic foreign bodies, or claustrophobia (applicable only to participants undergoing MRI); 3. Women who are confirmed pregnant, planning to become pregnant, or currently breastfeeding; 4. Individuals with primary diseases such as hepatic disorders, hematological diseases, or autoimmune diseases; 5. Participants with malignancies or psychiatric disorders; 6. Individuals with other severe comorbidities and a life expectancy of less than one year; 7. Individuals with poor compliance who are unable to attend regular follow-ups; 8. Participants diagnosed with rheumatoid arthritis, ankylosing spondylitis, or other inflammatory arthritides.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| General demographic information;Clinical data(Physical examination,Medical history,VAS pain scale,WOMAC scale,KOOS scale,PHQ-9 scale,SF-12 scale,etc.);Imaging examinations( knee anteroposterior and lateral plain radiographs,Dual-energy X-ray absorptiometry,knee MRI)MRI ;Bone mineral density (Femur (left) BMD, T-score, and Z-score; Lumbar spine (L1–L4) BMD, T-score, and Z-score; Total body muscle mass and total body fat mass);Incidence of metabolic diseases;Diet and Lifestyle; | — |
Countries
China
Contacts
Public ContactDing Changhai
Zhujiang Hospital of Southern Medical University
Outcome results
None listed