Intraoperative hypotension
Conditions
Interventions
Opioid-free anaesthesia:Adopting an opioid-free anesthesia protocol
Control group:Adopting an opioid-based anesthesia protocol
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Scheduled to undergo urological endoscopic surgery under general anesthesia 2.Aged >= 65 years 3.American Society of Anesthesiologists (ASA) physical status classification ?–? 4.Body mass index (BMI) ranging from 18 kg/m² to 30 kg/m²
Exclusion criteria
Exclusion criteria: 1. The patient declined to participate in the study 2. Allergy to dexmedetomidine, lidocaine, esketamine, and other drugs in this study 3. Long-term ß-blocker therapy, preoperative bradycardia HR<50bpm, with second or third degree atrioventricular block 4. Left ventricular ejection fraction (LVEF) <40% 5. History of intracranial hemorrhage or intracranial aneurysm 6. Use sedatives or painkillers before surgery 7. Chronic kidney or liver failure 8. Presence of language disorders, severe hearing or vision defects, etc 9. Previous history of neurological and psychiatric disorders, including Alzheimer's disease or other types of dementia or psychosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The blood pressure stability during the first 15 minutes after general anesthesia induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| The overall blood pressure stability during the operation;Blood pressure stability during the awakening period;The incidence of hypotension after anesthesia induction;Incidence of post-induction hypotension events;Cumulative dosage of norepinephrine;Postoperative recovery quality score; | — |
Countries
China
Contacts
Public ContactJianjun Yang
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed