Acute ischemic stroke, symptomatic carotid dissection
Conditions
Interventions
exposure group:EVT+SMT
control group:SMT
Sponsors
The Second Affiliated Hospital of the Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 18 =<age =<100; 1.The first onset was diagnosed as acute CAD by imaging examination. The symptoms included ischemic stroke or TIA confirmed by brain computed tomography (CT) or magnetic resonance imaging (MRI), headache confirmed by VAS, neck pain, Horner syndrome and neurological deficit confirmed by NIHSS score. 2.Written informed consent signed by patients or family members;
Exclusion criteria
Exclusion criteria: 1.Pregnant or lactating women; 2.mRS score>= 2 before onset; 3.Cardiogenic stroke or potential cardiogenic thrombosis, with any of the following clear causes of cardiogenic embolism: chronic or paroxysmal atrial fibrillation, mitral stenosis, mechanical valve, endocarditis, intracardial thrombus or implant, dilated cardiomyopathy, left atrial autoacoustic imaging; 4.Blood glucose22.2mmol/l, platelet3; 8.Expected failure to complete follow-up; 9.Brain hernia leads to midline displacement of brain; 10.Intracranial aneurysms, arteriovenous malformations; 11.Intracranial space occupying lesions; 12.Life expectancy185mmhg or diastolic blood pressure>110mmhg, and antihypertensive drugs can not be controlled; 14.Carotid artery dissection caused by iatrogenic or traumatic trauma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mRS score distribution at 90 days;24h symptomatic cerebral hemorrhage (Sich);90 day mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| mRS score 0-1 at 90 days (%);mRS score 0-3 at 90 days (%);Modified thrombolytic therapy for cerebral infarction (mtici) score;Changes of NIHSS score 24 hours after treatment;90 day EQ-5D scale score;mRS score 0-4 at 90 days (%);Changes of NIHSS score 48 hours after treatment;NIHSS score changes 5-7 days after treatment; If the time of discharge is earlier than 5-7 days, the time of discharge shall prevail;mRS score 0-2 at 90 days (%);mRS changes from baseline to 90 days (?mRS a sequential scale from -2, -1, 0, 1, 2, 3, 4, 5, 6); | — |
Countries
China
Contacts
Public ContactWenjie Zi
The Second Affiliated Hospital of the Army Medical University
Outcome results
None listed