Zoster-associated pain
Conditions
Sponsors
The second hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.The subjects were all hospitalized patients in our hospital; 2.Determine the previous history of herpes zoster, involving the neck, chest and lumbar ganglia, and conform to group A (acute phase of herpes zoster): from the onset of herpes zoster, the appearance of rash to the healing of skin lesions, the pain lasts for 1 month (the number of days from the onset of herpes zoster to the implementation of PRF = 1 month); Group B (postherpetic neuralgia): the diagnostic criteria of pain lasting for 1 month or more (the number of days between the onset of herpes zoster and the implementation of PRF>1 month) from the onset of herpes zoster, the appearance of rash to the healing of skin lesions; 3.Pain score (such as VAS score) >= 4 points; 4.Aged 50-80 years old, without severe heart, lung, liver, kidney and other organic diseases; 5.No psychosis or cognitive impairment; 6.Understand the various intervention measures in the experiment, and voluntarily participate in the experimental study; 7.There was no abnormality in MRI or X-ray examination of the spine at the corresponding lesion segment;
Exclusion criteria
Exclusion criteria: 1.The puncture site has infection, abnormal coagulation function, allergy to local anesthetics, systemic failure, malignant tumor, bacterial infection, etc; 2.Patients with autoimmune diseases such as systemic lupus erythematosus or recent use of immunosuppressive agents; 3.Patients with severe central nervous system complications; 4.Patients with obvious anxiety, depression or other diseases affecting pain perception; 5.Pregnant and lactating women; 6.Withdrawal during midway or follow-up;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| visual analogue scale,VAS;TNF-a;IL-8; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS-11;PSQI;PHQ-9;SF-36;Adverse reactions; | — |
Countries
China
Contacts
Public ContactLi Dongbai
The second hospital of Dalian Medical University
Outcome results
None listed