Presbycusis, noise-induced hearing loss, auditory neuropathy
Conditions
Interventions
Observation group:None
Sponsors
Beijing Chao-Yang Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1: (1) older than 60 years, no history of neurological disorder (e.g. stroke, epilepsy, multiple sclerosis, etc.) or mental disorders (e.g. depression, schizophrenia, bipolar disorder, etc.) All subjects had BMD =40 dB HL, and at least one ear high frequency hearing threshold mean >=25 dB HL (4) signed informed consent; 3: (1) ABR absent or severely abnormal (threshold >=80 dB HL) OAE or CM can be elicited (2) high-resolution temporal bone CT and craniocerebral MRI plain and oblique sagittal scans suggest no abnormalities in inner ear and auditory nerve development (3) two or more DPOAE tests are recommended (4) informed consent has been signed.
Exclusion criteria
Exclusion criteria: 1: (1) active otopathy (2) severe cognitive impairment (inability to care for oneself or complete dependence on others for care)(3) severe central system disease -LRB-severe cerebrovascular disease, brain tumor, etc.) ; 2: (2) History of otitis media, otosclerosis, Ménière's disease, acoustic neuroma, congenital deafness, familial deafness, drug-induced deafness (e.g. aminoglycosides, cisplatin) , non-noise-induced hearing loss (e.g. head trauma, temporal bone fracture, sudden deafness) , participation in other clinical trials or ototoxic drug therapy in the past 6 months, poor compliance, or the possibility of pseudo-deafness; 3: auditory neuropathy cohort (1) middle ear malformation, tympanic membrane perforation, cholesteatoma and other clear middle ear lesions (2) patients with incomplete clinical data and poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cohort Study of presbycusis;Cohort study of auditory neuropathy;Cohort study of noise-induced deafness; | — |
Countries
China
Contacts
Public ContactJuan Zhang
Beijing Chao-Yang Hospital
Outcome results
None listed