Hypertrophic obstructive cardiomyopathy
Conditions
Interventions
Ciprofol group:Use ciprofol for anesthesia induction. Patients were administered 0.4 mg/kg of ciprofol over a period of 30+/-10 s. Subsequently, monitor the depth of anesthesia based on MOAA/S scores
Propofol group:Use propofol for anesthesia induction.Intravenously administer propofol at 2.0 mg/kg over 30+/-10 s. Subsequently, monitor the depth of anesthesia based on MOAA/S scores and BIS values.
Sponsors
Beijing Anzhen Hospital Capital Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years 2. Scheduled for Modified Morrow surgery 3. New York Heart Association (NYHA) functional classes II to III 4. Left ventricular ejection fraction (LVEF) >= 45% 5. Signed informed consent
Exclusion criteria
Exclusion criteria: 1.severe cardiovascular 2.severe respiratory 3.severe hepatic, and renal insufficiency 4.psychiatric and neurological disorders (such as cerebrovascular disease, epilepsy, schizophrenia, depression) 5.moderate to severe cognitive impairment 6.anticipated difficult airway 7.unable to communicate or cooperate; allergy to anesthetic drugs or excipients (such as soybean oil, glycerol, egg); 8.a history of anaesthesia incidents
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence of post-induction hypotension (PIH) after general anesthesia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic parameters at each monitoring time point during induction;Total dosage of norepinephrine administered from the onset of induction to the start of surgery;Usage of study drugs;Time to successful induction;Occurrence of adverse events during induction;Renal function before surgery, during surgery, and within 24 hours after surgery;Liver function before surgery, during surgery, and within 24 hours after surgery;Changes in Bispectral Index (BIS);Maximum and minimum values of SBP, DBP, MAP, CO, and SVR from induction to the start of surgery;Volume of fluid replacement during induction;Evaluation of injection pain;Occurrence of postoperative delirium;Assessment of the occurrence of postoperative adverse events; | — |
Countries
China
Contacts
Public ContactMa Jun
Beijing Anzhen Hospital Capital Medical University
Outcome results
None listed