None
Conditions
Interventions
Opioid drugs combined with PENG block group(Group M):Opioid drugs combined with PENG block
Esketamine combined with PENG block group (Group E):Esketamine combined with PENG block
Sponsors
The Second Hospital of Shanxi Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age >= 65 years, any gender; 2. American Society of Anesthesiologists (ASA) classification: I–III; 3. Preoperative clinical indication for total hip arthroplasty (THA) treatment for the first time in patients undergoing total knee arthroplasty (TKA); 4. Type 2 diabetes with a disease course >= 1 year, without signs of diabetic peripheral neuropathy; 5. Cardiac function classification: I–III; 6. Patients who agree to receive postoperative analgesia; 7. Patients and their authorized representatives fully understand the content of this study and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients unsuitable for postoperative analgesia, such as those with infection at the puncture site or drug allergies; 2. Those with severe arrhythmias or liver and kidney dysfunction; 3. Patients who received local blockade treatment or long-term oral pain medication before surgery; 4. Those with a clear history of mental illness or alcohol and drug addiction; 5. Patients with severe central nervous system diseases who cannot undergo functional rehabilitation exercises; 6. Other individuals unsuitable for inclusion in the study, such as those with poor hearing, unclear expression, hemiplegia, long-term bedridden status, or limb disabilities.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MoCA score ; | — |
Secondary
| Measure | Time frame |
|---|---|
| GDS-15 score ;Serum S-100ß protein levels ;Activity NRS scores;Serum IL-6 levels ;Resting NRS scores;MoCA score one day before the operation and 48 hours after the operation;Serum Aß protein level; | — |
Countries
China
Contacts
Public ContactZhang Peng
The Second Hospital of Shanxi Medical University
Outcome results
None listed