Chloasma, wrinkles
Conditions
Interventions
Experimental group:This product is a liquid beverage, 25ml*2 bottles, combined with a stick of instant powder. Consume every morning, with meals or after meals.
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Female participants aged 25-55 years; 2. Fully capable of civil conduct, voluntarily sign the informed consent form, and agree to comply with the study protocol; 3. Presence of noticeable crow's feet with a grading of >=2 (according to the "Skin Aging Atlas 2 - Asians"); 4. Clinically diagnosed with stable mild to moderate melasma (duration >=6 months); 5. Have discontinued all topical or oral products with whitening/anti-wrinkle effects for >=4 weeks; 6. Commit to daily sun protection and avoiding intentional sun exposure during the study; 7. Will not change dietary habits during the study.
Exclusion criteria
Exclusion criteria: 1. Female participants who are pregnant, breastfeeding, or planning to become pregnant during the study period; 2. Existence of active skin diseases (including but not limited to eczema, rosacea, bacterial/fungal infections); 3. Diagnosed with autoimmune diseases or significant liver and kidney dysfunction; 4. Received cosmetic treatments such as laser therapy, chemical exfoliation, and soft tissue filling within the first 6 months of the study; 5. Long term use of systemic hormone drugs (continuous>3 months) or photosensitive drugs (such as tetracyclines and retinoids); 6. Individuals with previous hemorrhagic diseases, active gastrointestinal ulcers, thrombocytopenia, and difficulty controlling INR; 7. Those who are currently using anticoagulants such as warfarin/dabigatran/rivaroxaban or antiplatelet drugs such as aspirin and clopidogrel, and cannot discontinue or stabilize monitoring; 8. Using other dietary supplements (such as herbs and vitamins) within the past month; 9. Individuals who have received any treatment for melasma within the past month; 10. Known to have a history of allergies to pine tree extract, experimental formulation ingredients, or their excipients (medical record proof is required); 11. History of smoking or alcohol dependence; 12. Have a history of artificial sunbathing or exposure to strong ultraviolet radiation in tropical regions within the previous 3 months of the study (cumulative>2 weeks); 13. Individuals with previous photosensitive skin diseases or scar constitution; 14. Unable to guarantee compliance during the study period or the presence of other factors that may affect the determination of results; 15. Clinical evaluation suggests that participants are not suitable for the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Melasma MASI score;Wrinkle;Skin color;Pigmentation area;Uniformity of skin tone;Skin melanin;Safety assessment (including any adverse reactions, such as erythema, edema, papules, stinging, etc.); | — |
Secondary
| Measure | Time frame |
|---|---|
| Skin glossiness;Skin elasticity;Dermal echo intensity;Skin roughness ;Loss rate of epidermal water diversion;Moisture content of skin stratum corneum; | — |
Countries
China
Contacts
Public ContactWang Xi
West China Hospital, Sichuan University
Outcome results
None listed