Skip to content

Study on preoperative use of oxycodone hydrochloride to reduce pain and promote rehabilitation after knee arthroplasty

Application of preventive opioid analgesia strategy in total knee arthroplasty: a prospective randomized controlled trial of the effect of preoperative oxycodone hydrochloride on postoperative pain management and functional recovery

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600116918
Enrollment
Unknown
Registered
2026-01-16
Start date
2026-01-19
Completion date
Unknown
Last updated
2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total knee arthroplasty for end-stage knee disease

Interventions

Sponsors

The Fifth Affiliated Hospital of Zhengzhou University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.Patients undergoing primary total knee arthroplasty due to end-stage knee disease; 2.Preoperative platelet and coagulation functions were normal; 3.Preoperative color Doppler ultrasound of both lower extremity veins showed no abnormality; 4.Patients with good compliance voluntarily and signed informed consent; 5.Be able to fully understand the visual analogue scale (VAS) of pain;

Exclusion criteria

Exclusion criteria: 1.Allergy to local anesthetic drugs involved in the study; 2.The compliance was so poor that it was impossible to complete the visual analogue scale (VAS) evaluation of pain; 3.Previous or recent history of opioid use; 4.Unable to tolerate anesthesia and surgery; 5.Patients with severe liver and kidney dysfunction;

Design outcomes

Primary

MeasureTime frame
Static visual analogue scale;Dynamic visual analogue scale;Joint mobility;Active straight leg raising time;Knee flexion 90 ° time;

Secondary

MeasureTime frame
Incidence of postoperative adverse reactions;Total number of hospital days;

Countries

China

Contacts

Public ContactYan Peng

The Fifth Affiliated Hospital of Zhengzhou University

17310852001@163.com+86 17310852001

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026