hyperalgesia
Conditions
Interventions
control group:intravenous 0.9% NaCl
experimental group:Intravenous injection of Anrikefon Infusion (HSK21542), dose: 1µg/kg
Sponsors
Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Patients and their families are informed and voluntarily agree to participate in the study, and have signed the informed consent form. (2) Patients scheduled to undergo elective unilateral single-port thoracoscopic lobectomy or partial lobectomy. (3) American Society of Anesthesiologists (ASA) physical status classification of I to III; aged 18 to 75 years; no restrictions on gender.
Exclusion criteria
Exclusion criteria: (1) Body Mass Index (BMI) >= 35 kg/m². (2) Known history of opioid abuse or dependence. (3) Current chronic use of opioids, antidepressants, and/or anticonvulsants. (4) Moderate to severe chronic obstructive pulmonary disease (COPD), defined as forced expiratory volume in one second (FEV1) < 50% of predicted value. (5) Chronic renal insufficiency. (6) Diabetes mellitus. (7) Peripheral neuropathy. (8) History of preoperative neoadjuvant radiotherapy or chemotherapy. (9) Inability to independently manage postoperative patient-controlled intravenous analgesia. (10) High risk for sleep apnea syndrome as assessed by the STOP-BANG questionnaire.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of surgical incision hyperalgesia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative hydromorphone and rescue analgesic consumption.;Incidence of chronic postsurgical pain.;Postoperative pain scores.;Opioid-related adverse effects.;total consumption of remifentanil;Patient satisfaction.;Postoperative Quality of Recovery.;Incidence of nausea and vomiting.;Incidence of hyperalgesia contralateral to the surgical incision;Range of surgical incision hyperalgesia; | — |
Countries
China
Contacts
Public ContactShu Haihua
Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences)
Outcome results
None listed