Acute aortic dissection
Conditions
Interventions
Gold Standard:The gold standard: Use CTA to show "aortic intimal tear and true or false lumen formation" or the dissection rupture under direct vision during surgery as the basis for the diagnosis of
Index test:soluble suppression of tumorigenicity 2, sST2
Sponsors
Guangdong Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old, with the onset time of "acute chest pain" (sudden pain in the chest, back, abdomen, etc.) <=24 hours and visiting the emergency department; 2. Clinically suspected AAD (tearing pain, bilateral blood pressure asymmetry, abnormal pulse, shock and other signs, or imaging suggesting aortic widening, etc.); 3. All completed the detection of sST2, D-dimer, troponin, brain natriuretic peptide and aortic Computed tomography angiography (CTA) examination; 4. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. The time from the onset of the disease to seeking medical attention is more than 24 hours; 2. Combined with other known diseases that affect sST2 levels; Such as acute and chronic heart failure, fulminant myocarditis, etc. 3. The sample is hemolyzed, lipemic or collected improperly; 4. The patient has a history of immune deficiency diseases (such as HIV, etc.), or a history of cancer, malignant tumors, or autoimmune diseases, or severe cardiovascular and cerebrovascular diseases, or other diseases that may significantly reduce life expectancy; 5. Have any medical history that may affect compliance with the protocol (such as severe mental disorders, cognitive dysfunction, drug abuse or addiction, etc.); 6. Pregnant or lactating women, or those who are fertile but unwilling or unable to take effective contraceptive measures; 7. Patients who the researcher determined were not suitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| soluble suppression of tumorigenicity 2;Whole aortic CTA;Troponin;Brain natriuretic peptide; | — |
Secondary
| Measure | Time frame |
|---|---|
| D-Dimer; | — |
Countries
China
Contacts
Public ContactHu Bei
Guangdong Provincial People's Hospital
Outcome results
None listed