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The effect of pyridoxine on the incidence of PONV after laparoscopic cholecystectomy in patients with moderate to high risk Apfel scores

The effect of pyridoxine on the incidence of PONV after laparoscopic cholecystectomy in patients with moderate to high risk Apfel scores

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600116881
Enrollment
Unknown
Registered
2026-01-16
Start date
2026-01-22
Completion date
Unknown
Last updated
2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative nausea and vomiting

Interventions

Pyridoxine group ( group P):The pyridoxine group (P group) received an intravenous injection of 0.2 grams of vitamin B6, which was diluted to 5 milliliters with physiological saline.
Control group (Group C):The control group (Group C) received intravenous injection of an equal amount of 5 milliliters of physiological saline.

Sponsors

Lishui People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.Age requirement: = 18 years old and= 2 points; 4. Willing to sign an informed consent form.

Exclusion criteria

Exclusion criteria: 1. Patients with preoperative psychiatric disorders or communication difficulties who find it difficult to receive postoperative follow-up normally; 2. Long term use of antiemetic drugs, opioid drugs, or glucocorticoids; 3. Have a history of allergies to the drugs involved in the study; 4. Other diseases that may manifest as nausea or vomiting, such as hepatitis or gastric ulcers; 5. Suffering from other serious comorbidities, the researchers believe that it is not suitable to participate in this study.

Design outcomes

Primary

MeasureTime frame
Postoperative nausea and vomiting incidence rate;

Secondary

MeasureTime frame
Postoperative nausea and vomiting degree;Postoperative recovery quality;Adverse event incidence rate;Pain score for rest and exercise 24 hours after surgery;postoperative morphine equivalent dose within 24 hours after surgery;The demand for postoperative rescue antiemetic drugs;

Countries

China

Contacts

Public ContactDuan Gongchen

Lishui People's Hospital

981225178@qq.com+86 189 5709 3030

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026