Ulcers after Esophageal Endoscopic Submucosal Dissection
Conditions
Interventions
PRP Group:In the PRP group, 1 mL of PRP was injected submucosally at each of four points around the periphery of the ESD-induced ulcer immediately after the procedure, for a total administered volume
Control Group:Patients in the control group received standard ESD only, with no additional intervention.
Sponsors
Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Voluntary participation, confirmed by written informed consent. 2.Aged between 18 and 80 years. 3.Diagnosis of early-stage esophageal squamous cell carcinoma or precancerous lesions, with an elective ESD procedure planned. 4. Ability and willingness to adhere to the follow-up schedule, report symptoms accurately, and complete all required questionnaires.
Exclusion criteria
Exclusion criteria: 1. Patients with severe organ dysfunction affecting the heart, brain, lungs, liver, kidneys, or other vital organs; 2. Patients requiring ESD for multiple lesions; 3. Patients with a history of thoracic or abdominal surgery; 4. Patients with a confirmed history of infection prior to surgery, such as pneumonia, upper respiratory tract infection, or urinary tract infection; 5. Pregnant or breastfeeding women; 6. Patients with severe coagulation disorders; 7. Contraindications for PRP use: (1) platelet dysfunction syndrome; (2) severe thrombocytopenia; (3) haemodynamic instability; (4) sepsis; (5) localised infection; 8. Any other reason deemed ineligible by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| healing rate of ulcer; | — |
Secondary
| Measure | Time frame |
|---|---|
| Operating hours;Site of pathology;Intraoperative haemorrhage; | — |
Countries
China
Contacts
Public ContactFangyu Wang
Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University
Outcome results
None listed