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Efficacy Comparison of Volume-Stable Collagen Matrix Loaded with Fibroblast Growth Factor Versus Connective Tissue Graft for Treating Multiple RT 1 Gingival Recessions: A Non-Inferiority Randomized Controlled Clinical Trial

Efficacy Comparison of Volume-Stable Collagen Matrix Loaded with Fibroblast Growth Factor Versus Connective Tissue Graft for Treating Multiple RT 1 Gingival Recessions: A Non-Inferiority Randomized Controlled Clinical Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600116839
Enrollment
Unknown
Registered
2026-01-15
Start date
2026-01-15
Completion date
Unknown
Last updated
2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingival recession

Interventions

Collagen Matrix Group:Using a volume-stable collagen matrix combined with recombinant human basic fibroblast growth factor
Connective Tissue Graft Group:Connective tissue graft

Sponsors

Stomatology Hospital,Zhejiang University School Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Age 18-50 and in good overall health; 2. Two or more teeth with Cairo Classification RT1 gingival recession, with a recession depth >= 2mm; 3. No untreated periodontal disease; 4. Full-mouth plaque and bleeding index <20%; 5. Cementoenamel junction (CEJ) of affected teeth identifiable.

Exclusion criteria

Exclusion criteria: 1. Heavy smokers (>10 cigarettes/day); 2. Pregnant or breastfeeding women; 3. Patients with uncontrolled systemic diseases (such as diabetes, immune system disorders, etc.); 4. Patients with severe dental misalignment or rotation; 5. Patients using medications that may affect mucosal healing (steroids, immunosuppressants) or with a history of head and neck radiotherapy; 6. Patients with a history of periodontal surgery in the surgical area; 7. Patients allergic to porcine-derived collagen or recombinant human basic fibroblast growth factor, or for whom its use is contraindicated.

Design outcomes

Primary

MeasureTime frame
complete root coverage;Mean Root Coverage;

Secondary

MeasureTime frame
Soft tissue volume change;Probing Depth;Pain Assessment;Gingival Thickness;Complication Rate;Width of keratinized gingiva;Recession Depth;Root Coverage Esthetic Score;

Countries

China

Contacts

Public ContactDing Peihui

Stomatology Hospital, Zhejiang University School Medicine

phding@163.com+86 571 87219927

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026