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Comparison of autologous vascular matrix components with adipose mesenchymal stem cells combined with self-setting calcium phosphate artificial bone and iliac bone transplantation for the treatment of early to mid-stage femoral head necrosis - a randomized controlled study.

Analysis of the Safety and Efficacy of Multiple Injections of Autologous Vascular Matrix Components Combined with Self-Setting Calcium Phosphate Artificial Bone and Iliac Bone Grafting for the Treatment of Early to Mid-Stage Osteonecrosis of the Femoral Head

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600116823
Enrollment
Unknown
Registered
2026-01-15
Start date
2026-01-16
Completion date
Unknown
Last updated
2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteonecrosis of the Femoral Head

Interventions

SVF treatment group: 1. During the surgery, SVF is first extracted from the patients autologous adipose tissue using specific isolation techniques, then self-setting calcium phosphate artificial bone
ADSC treatment group: 2. After obtaining the patients autologous adipose tissue, the ADSC is obtained using in vitro separation, culture, and amplification techniques. After completing the implantati

Sponsors

Chinese People's Liberation Army General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria include: age between 18 and 65 years; voluntary participation in this study and signing the informed consent form.

Exclusion criteria

Exclusion criteria: Combined with severe cardiovascular and cerebrovascular diseases, hematologic diseases, and infectious diseases; contraindications for surgery and related treatments; recently received other interventions affecting the treatment of femoral head necrosis.

Design outcomes

Primary

MeasureTime frame
Imaging assessment;—

Secondary

MeasureTime frame
Assessment of hip joint function;Assessment of pain degree;Sppraisal of life quality;Safety assessment;—

Countries

China

Contacts

Public ContactPeng Jiang

Chinese People's Liberation Army General Hospital

pengjiang301@126.com+86 139 1006 0749

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026