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A study on the mechanism by which functional near-infrared-based aerobic-cognitive dual-task training regulates the dorsolateral prefrontal cortex to improve the central sensitization of brain function in knee osteoarthritis

A study on the mechanism by which functional near-infrared-based aerobic-cognitive dual-task training regulates the dorsolateral prefrontal cortex to improve the central sensitization of brain function in knee osteoarthritis

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600116813
Enrollment
Unknown
Registered
2026-01-15
Start date
2026-02-28
Completion date
Unknown
Last updated
2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee osteoarthritis

Interventions

Aerobic Exercise Group:This study selected a power bike as the main aerobic exercise tool. For participants who meet the aerobic exercise criteria, training will be conducted according to an aerobic e
Cognitive - Aerobic Training Group:Perform aerobic exercise (AEG) while simultaneously engaging in cognitive training
Control group:Undergo 12 weeks of infrared therapy and ultrasound therapy

Sponsors

Shanghai University of Sport
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Age between 50-80 years; 2. Recurrent knee pain in the past month (disease duration of 3 months or more); 3. Experiencing two or more types of knee pain symptoms during the following daily activities: (1) Prolonged sitting; (2) Climbing stairs; (3) Squatting; (4) Running; (5) Kneeling; (6) Jumping; 4. Knee X-ray shows joint space narrowing or osteophyte formation; 5. According to the Kellgren-Lawrence grading system: Grade II-IV.

Exclusion criteria

Exclusion criteria: 1. Other knee joint injuries, such as a history of patellar dislocation, fractures, meniscus tears, etc.; 2. Patients with a history of mental illness or intellectual disabilities; 3. Patients with severe cardiovascular diseases, neurological disorders, osteoporosis, or metabolic diseases.

Design outcomes

Primary

MeasureTime frame
Numerical rating scale;Western Ontario and McMaster Universities Osteoarthritis Index, WOMAC;cerebral hemodynamics;Surface electromyography;Short Form-12;

Secondary

MeasureTime frame
Pressure Pain-threshold;Hot Pain Tolerance;International physical activity questionnaire;Pittsburgh sleep quality index;Pain catastrophizing scale Score;Fear avoidance beliefs questionnaire;Pain self-efficacy questionnaire;Neuromuscular function of the knee joint;cognitive function;Self-rating anxiety Score;Self-rating depression scale Score;

Countries

China

Contacts

Public ContactPeijie Chen

Shanghai University of Sport

chenpeijie@sus.edu.cn+86 137 0191 0268

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026