Sepsis and its related encephalopathy
Conditions
Interventions
Healthy Control Group:None
Sepsis patient group:sepsis
Sponsors
The First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Healthy Control Group (1) Age must be >= 18 years and = 18 years and = 2 points in SOFA score on the basis of suspected or confirmed infection; (3) The subject or their legal representative voluntarily participates in the study and signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Healthy Control Group (1) Presence of acute infection or history of infection within the past 1 month; (2) History of or current clear central nervous system disease or severe psychiatric disorder; (3) Coexistence of malignancy, severe hepatic or renal dysfunction, or other severe chronic systemic diseases; (4) Long-term use of immunosuppressants, glucocorticoids, or biologics; (5) Pregnant or lactating females; (6) Other conditions deemed unsuitable for inclusion in the study by the investigator. 2. Sepsis Patient Group (1) History of clear central nervous system disease (e.g., stroke, epilepsy, encephalitis, sequelae of traumatic brain injury) or severe psychiatric disorder; (2) Coexistence of malignancy, severe hepatic or renal dysfunction, or long-term high-dose glucocorticoid use; (3) Presence of severe chronic systemic disease (e.g., end-stage cardiac insufficiency, end-stage pulmonary disease) or clear autoimmune disease; (4) Received radiotherapy or chemotherapy within the past 3 months; (5) Currently using immunosuppressants or biologics; (6) Pregnant or lactating females; (7) Other conditions deemed unsuitable for inclusion in the study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RBM15B levels in peripheral blood mononuclear cells;Routine laboratory tests: White blood cell count (WBC), hemoglobin (Hb), platelet count (PLT), C-reactive protein (CRP), serum albumin, AST, ALT, creatinine (Cr), estimated glomerular filtration rate (eGFR), and electrolytes.;Cognitive Function and SAE Assessment; | — |
Countries
China
Contacts
Public ContactMo Yunchang
The First Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed