Colorectal cancer
Conditions
Interventions
Experimental Group: Butorphanol Group (B Group):Postoperative Analgesia Management:Intravenous injection of butorphanol 25 µg/kg (diluted to 10 mL, administered over 5 minutes) before peritoneal closu
Control Group: Sufentanil Group (S Group):Postoperative Analgesia:Intravenous injection of sufentanil 0.2 µg/kg (diluted to 10 mL, administered over 5 minutes) before peritoneal closure.Postoperative
Sponsors
Sanya Central Hospital (Hainan Third People's Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Meets the diagnostic criteria for colorectal cancer in the Chinese Guidelines for Diagnosis and Treatment of Colorectal Cancer (2020 Edition) [12] and is staged according to the TNM staging criteria of the 7th edition of the American Joint Committee on Cancer [13]; 2. Has no tumor metastasis to surrounding or adjacent tissues and organs before surgery; 3. Age >= 18 years and <= 75 years, American Society of Anesthesiologists (ASA) grade I or I, that is, the organ system function is normal or fully compensated; 4. Has not used analgesics before surgery; 5. Patients voluntarily participate in this study.
Exclusion criteria
Exclusion criteria: 1. History of abdominal surgery; 2. Acute infection, autoimmune disease or chronic inflammatory disease; 3. Patients who have undergone palliative surgical resection; 4. History of allergy to anesthetic drugs or drug abuse; 5. Patients with liver or kidney dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative 6-hour rest/cough VAS score;Postoperative 12-hour rest/cough VAS score;Postoperative 24-hour rest/cough VAS score;Postoperative 48-hour rest/cough VAS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Immunological Parameters: Peripheral blood Th17 cell levels;Immunological Parameters:Peripheral blood Treg cell levels ;Blood loss;Blood transfusion volume;Operative time;hospitalization duration;time to first flatus;incidence of nausea and vomiting;postoperative infection rate; | — |
Countries
China
Contacts
Public ContactXu Xia
Sanya Central Hospital (Hainan Third People's Hospital)
Outcome results
None listed