Lumbar spinal stenosis and lumbar disc herniation
Conditions
Interventions
Intervention group:Local application of bovine collagen–gelatin hydrogel loaded with dexamethasone (10 mg) at the surgical site after surgery.
Control group:Local application of bovine collagen–gelatin hydrogel loaded with normal saline at the surgical site after surgery.
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis of lumbar spinal stenosis or lumbar disc herniation. 2. Failure of conservative treatment and scheduled for lumbar fusion surgery or lumbar discectomy. 3. Provision of written informed consent. 4. Single-level surgery. 5. No other conditions known to cause low back and/or leg pain.
Exclusion criteria
Exclusion criteria: 1. Extremely low pain threshold or psychological instability resulting in inability to comply with the study procedures. 2. Known allergy to the intraoperative study drug mixture. 3. Pregnancy. 4. History of lumbar fusion surgery. 5. Age < 18 years. 6. Non-degenerative etiologies, such as spinal trauma or spinal tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score (Visual Analog Scale score); | — |
Secondary
| Measure | Time frame |
|---|---|
| ODI score (Oswestry Disability Index score);Lumbar JOA score (Japanese Orthopaedic Association score for the lumbar spine);Use of rescue analgesics (rescue pain medication); | — |
Countries
China
Contacts
Public ContactXinyu Liu
Qilu Hospital of Shandong University
Outcome results
None listed