Helicobacter pylori
Conditions
Interventions
bismuth quadruple therapy group:Esomeprazole+Amoxicillin+Furazolidone+Colloidal Bismuth Pectin
Sponsors
Northern Jiangsu People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients aged 18–70 years, regardless of gender; 2. A history of at least one failed course of H. pylori eradication therapy; 3. Confirmed H. pylori infection, as diagnosed by a positive result in any one of the following tests: ¹³C/¹4C-urea breath test, rapid urease test, stool antigen test, histology, or bacterial culture; 4. Provision of informed consent and voluntary participation in the study.
Exclusion criteria
Exclusion criteria: 1. Individuals who are allergic to the study medication; 2. Those who have used antibiotics, bismuth preparations, and probiotics in the past 4 weeks or potassium-competitive acid blockers (P-CABs), proton pump inhibitors (PPIs), or H2-receptor antagonists in the past 2 weeks; 3. Previous receipt of the identical treatment regimen used in either the experimental group or the control group; 4. Current pregnancy, lactation, or pregnancy planning; 5. Complicated by severe diseases of the heart, liver, lungs, kidneys, or other vital organs, or concomitant diagnosis of gastrointestinal malignancy; 6. Inability to cooperate with the study due to alcoholism, substance abuse, severe mental illness, or other relevant conditions..
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Helicobacter pylori eradication rate ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events;Compliance; | — |
Countries
China
Contacts
Public ContactBen-Gang Zhou
Northern Jiangsu People's Hospital
Outcome results
None listed