Parkinson's Disease
Conditions
Interventions
Sensory-motor cortical paired associative TMS (sm-PAS) group:Sensory-motor cortical paired associative TMS
Sham TMS group(S-TMS):Sham TMS
Single-site motor cortex TMS (m-TMS) group:Single-site motor cortex TMS
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
No minimum to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged < 75 years; 2. Diagnosis of PD according to the Diagnostic Criteria for Parkinson’s Diseas; 3. Hoehn–Yahr stage III–IV; 4. Presence of balance and gait impairments, as indicated by the Mini Balance Evaluation Systems Test less than 20 points; 5. Mini-Mental State Examination score more than 24, indicating no significant cognitive impairment and adequate ability to comprehend and follow therapist instructions; 6. Receiving stable pharmacological treatment for PD; 7. Absence of other neurological disorders; 8. The individual or their legal guardian has the capacity to provide informed consent.
Exclusion criteria
Exclusion criteria: 1.Contraindications to transcranial magnetic stimulation according to the guidelines; 2.Severe cardiac, pulmonary, hepatic, or renal insufficiency, or uncontrolled malignant hypertension precluding participation in exercise; 3.Severe psychiatric conditions, severe malnutrition, severe osteoporosis, unhealed fractures, or other significant musculoskeletal disorders that could interfere with completion of exercise; 4.Lower limb dysfunction attributable to causes other than PD.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-Balance Evaluation Systems Test (Mini-BESTest); | — |
Secondary
| Measure | Time frame |
|---|---|
| Movement Disorder Society-Sponsored Unified Parkinson's Disease Rating Scale Part III (MDS-UPDRS-III);39-item Parkinson's Disease Questionnaire (PDQ-39);Neuroimaging measures;Neuroelectrophysiological measure; | — |
Countries
China
Contacts
Public ContactMeng Lijiao
West China Hospital of Sichuan University
Outcome results
None listed