Acute kidney injury
Conditions
Interventions
Renal rSO2-targeted anesthesia management group:Intraoperatively, renal tissue oxygen saturation (SstO2) is used as a management target, with recommended interventions applied to maintain SstO2 within
Conventional anesthesia management group:Intraoperatively, mean arterial pressure is the management target, with routine clinical hemodynamic measures—such as fluid administration, vasopressor use, an
Sponsors
Tianjin First Central Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 17 Years
Inclusion criteria
Inclusion criteria: 1. Age <18 years; 2. First-time living donor liver transplantation; 3. Informed consent obtained from patients willing to participate in the trial.
Exclusion criteria
Exclusion criteria: 1. Pre-existing extrahepatic organ failure; 2. Congenital heart disease or other severe malformations; 3. Preoperative renal impairment or requirement for renal replacement therapy (RRT); 4. Long-term preoperative use of medications with known nephrotoxicity;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The increase in serum creatinine relative to preoperative baseline levels within 7 days postoperatively.; | — |
Countries
China
Contacts
Public ContactDong Aili
Tianjin First Central Hospital
Outcome results
None listed