Acute Heart Failure
Conditions
Interventions
Control Group:Conventional treatment
Trial Group:Recombinant human brain natriuretic peptide (rhBNP)
Sponsors
Ningdu County People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age range: 18 to 75 years old (inclusive). 2.Fulfill the diagnostic criteria for acute heart failure according to the Chinese Guidelines for the Diagnosis and Treatment of Heart Failure 2024. 3.NYHA Class III to IV (per the New York Heart Association functional classification). 4.Willingness to participate in the trial and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Cardiogenic Shock; 2.(Patients) with other serious diseases and a life expectancy of less than 12 months. 3.Women who are pregnant, breastfeeding, or planning to become pregnant within the next 3 months. 4.Severe renal insufficiency, with an estimated glomerular filtration rate (eGFR) of less than 15 mL/min/1.73 m^2. 5.Major organ dysfunction or failure. 6.History of alcohol or drug abuse. 7.Patients with an anticipated hospital stay of 24 hours or less. 8.Patients with a systolic blood pressure (SBP) of less than 90 mmHg. 9.Patients who are likely to have difficulties with study participation or follow-up (e.g., due to non-compliance or legal incompetence). 10.Allergy to the study drug(s). 11.Participation in another clinical trial within the past month. 12.Patients for whom vasodilators are not suitable, including but not limited to those with: severe valvular stenosis; restrictive or obstructive cardiomyopathy; constrictive pericarditis; cardiac tamponade; or other conditions in which cardiac output is dependent on venous return or where low cardiac filling pressure is suspected. 13.Any other condition that, in the opinion of the investigator, may pose a risk to the patient.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NT-proBNP;Comparison of the percentage change from baseline in NT-proBNP levels after 3 days of treatment between the two groups of patients; | — |
Countries
China
Contacts
Public ContactZeng Hui
Ningdu County People's Hospital
Outcome results
None listed