Chronic insomnia with depression
Conditions
Interventions
Group A:Standard treatment
Group B:Dexmedetomidine combined with esketamine treatment
Sponsors
The People's Hospital of Shihotze City, Xinjiang
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients with depression aged 18-65 years, regardless of gender, ASA class I-II, meeting the diagnostic criteria for chronic insomnia as outlined in the Chinese Guideline for the Diagnosis and Treatment of Insomnia in Adults (2017 edition). 2. Prior to hospitalization, all patients received conventional treatment according to the Chinese Guideline for the Diagnosis and Treatment of Insomnia in Adults (2017 edition). The treatment involved more than two types of medications, lasted for over 3 months, and yielded poor or ineffective results. The Pittsburgh Sleep Quality Index (PSQI) score before hospitalization was >9, leading to a diagnosis of chronic primary insomnia. 3.All patients met the diagnostic criteria for depression as per the International Classification of Diseases, 11th Revision (ICD-11). The Hamilton Depression Scale (HAMD) score was >8, and the Self-Rating Depression Scale score was >52.
Exclusion criteria
Exclusion criteria: 1. Patients with sleep apnoea syndrome; 2. Patients with a history of epilepsy; 3. Patients with known alcohol abuse or drug dependency; 4. Pregnant or breastfeeding patients; 5. Patients with a history of severe head trauma; 6. Patients anticipated to present with difficult airways or severe respiratory insufficiency; 7. Patients with a history of allergy to dexmedetomidine or esketamine; 8. Patients unable to comprehend the content of relevant assessment scales.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pittsburgh Sleep Quality Index;Hamilton Depression Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Self-Rating Depression Scale;Somatization Symptom Self-rating Scale;Epworth Sleepiness Scale;Self-Rating Anxiety Scale; | — |
Countries
China
Contacts
Public ContactChen Dan
The People's Hospital of Shihotze City, Xinjiang
Outcome results
None listed