Poor embryo quality
Conditions
Interventions
Endometrial epithelial cell co-culture group:This is a pilot study aiming to enroll 30 patients initially.
Endometrial epithelial cell co-culture group:
Endometrial epithelial cells are thawed 1 wee
Sponsors
Reproductive and Genetic Hospital of CITIC-XIANGYA
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Patients with poor embryo quality in >=2 prior assisted reproduction cycles at other hospitals or our hospital, including those with fragmentation rate >=60%, arrest at cleavage stage, or good-quality cleavage-stage embryos but blastocyst formation rate =2.0; 5. Voluntarily signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Use of donor sperm or donor eggs for assisted reproduction; 2. Planning to undergo time-lapse embryo monitoring; 3. Number of normally fertilized oocytes (2PN) <2; 4. Contraindications to pregnancy or contraindications to assisted reproductive technology.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Utilization rate of blastocysts from 2PN (number of usable blastocysts on Day 5–7 / number of 2PN);Secondary endpoints: Day 2 good embryo rate, Day 2 top embryo rate, Day 3 good embryo rate, Day 3 top embryo rate, blastocyst formation rate (Day 5–7), high-quality blastocyst formation rate, embryo degeneration rate, clinical pregnancy rate, implantation rate, early miscarriage rate, ongoing pregnancy rate; | — |
Countries
China
Contacts
Public ContactZhang Shuoping
Reproductive and Genetic Hospital of CITIC-XIANGYA
Outcome results
None listed