Major depressive disorder
Conditions
Interventions
MDD group:Sertraline or drugs combined with DBT group
Healthy group:None
Sponsors
University City Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Adolescents with depression (1) Meet the DSM-V diagnostic criteria for depression and meet the major depressive episode of MINI-kid; (2) Han nationality, aged 12-18 years old, right-handed, primary school education or above; (3) Hamilton Depression Scale (HDRS17) item score >=17 points; (4) First untreated depression patients or nearly 1 month without drug treatment history, nearly 1 month without electroconvulsive therapy history; 2. Healthy control group (1) Han nationality, aged 12-18 years old, right-handed, primary school education or above; (2) Never had any neurological or psychiatric diseases (3) No magnetic resonance contraindications; (4) No claustrophobia.
Exclusion criteria
Exclusion criteria: 1. combined with other mental diseases; 2. Combined with organic brain disease or history of severe brain trauma; 3. combined with other serious physical diseases; 4. There are magnetic resonance scanning contraindications; 5 a history of substance dependence or abuse; 6. Not actively cooperating with researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale,HAMD;Hamilton Anxiety Scale,HAMA;Children's Depression Rating Scale--Revised;Ottawa Self-injury Inventory;Nine-item Patient Health Questionnaire,PHQ-9;Beck Scale for Suicide Ideation, SSI;The Childhood Trauma Questionnaire—Short Form (CTQ-SF);Brain magnetic resonance; | — |
Secondary
| Measure | Time frame |
|---|---|
| The Columbia-Suicide Severity Rating Scale (C-SSRS);Children's Depression Inventory,CDI;The Multidimensional Anxiety Scale for Children (MASC);Udvalg for Kliniske Undersogelser;Gross Rating Scale;General Anxiety Disorder-7;Patient Health Questionnaire 15;Perceived Deficit Questionnaire for Depression, PDQ-D;Adolescent Self-rating Life Events Checklist,ASLEC;Connor—Davidson resilience scale,CD—RISC;Impulsive Behavior Scale, IBS;Emotion Regulation Questionnaire,ERQ; | — |
Countries
China
Contacts
Public ContactKuang Li
University City Hospital of Chongqing Medical University
Outcome results
None listed