General anesthesia for elderly patients
Conditions
Interventions
Disodium phosphopropofol group:Sufentanil citrate injection 0.4µg/kg was administered intravenously first
Then, administer disodium phosphopropofol at a dose of 10-15mg/kg slowly (30-60 seconds). When the appropriate sedation depth (MOAA/S <=1) is reached, a muscle relaxant: rocuronium 0.6mg/kg is adminis
Remimazolam besylate group:Sufentanil citrate injection 0.4µg/kg was administered intravenously first
Remimazolam benzenate at a dose of 0.2-0.3mg/kg is administered slowly (30-60 seconds) until an appropriate depth of sedation (MOAA/S <=1) is achieved. Then continue to administer muscle relaxants: ro
Propofol group:Sufentanil citrate injection 0.4µg/kg was administered intravenously first
Propofol 1-1.5mg/kg, administered slowly (30-60 seconds) until an appropriate sedation depth (MOAA/S <=1) is achieved. Then continue to administer muscle relaxants: rocuronium 0.6 mg/kg, and perform t
Sponsors
Tai'an Central Hospital (Qingdao University Affiliated Tai'an Central Hospital, Taishan Medical Care Center)
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age: 65-80 years old; (2) American Society of Anesthesiologists (ASA) : Grades I - III; (3) Body Mass Index (BMI) : 18.5-30 kg/m ²; (4) For subjects who need to undergo elective surgery under general anesthesia, the estimated operation time is more than 1 hour; (5) Participate voluntarily and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Combined with severe diseases of the cardiovascular, respiratory, liver, kidney or central nervous system; (2) There is a difficult airway or it has been determined that tracheal intubation is difficult (modified Markov scale grade III or IV); (3) Uncontrolled diabetes or hypertension; (4) History of drug abuse, alcoholism or drug dependence; (5) Abuse or long-term use of anesthetic, sedative and analgesic drugs; (6) Those who are known or suspected of being allergic to or contraindicated to the various components of the investigational drug or the procedural medication specified in the protocol (such as opioids, propofol, disodium phosphopropofol, remimazolam besylate, muscle relaxants, etc.); (7) Patients with a history of mental illness, who had delirium or cognitive dysfunction before the operation; (8) Frail patients; (9) Those who have participated in any drug clinical trials within one month prior to screening; (10) Subjects who the researchers consider to have any other factors that make them unsuitable for participating in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of post-induction hypotension; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative recovery quality score;The frequency of hypotension after induction;Hemodynamic indicators;Dosage of the drug;The use of vasoactive drugs during the operation;Effectiveness and recovery indicators; | — |
Countries
China
Contacts
Public ContactShenqiang Gao
Tai'an Central Hospital (Qingdao University Affiliated Tai'an Central Hospital, Taishan Medical Care Center)
Outcome results
None listed