Knee Degenerative Joint Disease
Conditions
Interventions
Control group:After general anesthesia induction, ultrasound-guided injection of ropivacaine hydrochloride was performed for posterior joint capsule space block (0.25%, 20ml) combined with adductor mu
Experimental Group:After general anesthesia induction, a liposomal bupivacaine injection was performed under ultrasound guidance for posterior joint capsule space block (20ml) combined with adductor m
Sponsors
The Second People's Hospital of Hefei
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. ASA anesthesia classification: Grade I - III; 2. Age: 18 years old to 90 years old, gender not restricted; 3. BMI: 18 - 30 kg/m^2; 4. Scheduled for total knee replacement under general anesthesia; 5. Able to understand and voluntarily sign the informed consent form, and willing to comply with the requirements of the trial protocol.
Exclusion criteria
Exclusion criteria: 1.Patients with hypersensitivity or contraindications to bupivacaine liposomes or other anesthetic agents; 2.Those with severe cardiac, pulmonary, or renal insufficiency, multiple chronic conditions that make them intolerant to surgical anesthesia, or psychiatric disorders; 3.Individuals with alcohol abuse history, opioid allergy, or history of opioid drug abuse; 4.Patients with impaired language, cognitive, or comprehension abilities that prevent normal communication; 5.Pregnant or breastfeeding women; 6.Emergency surgery patients; 7.Other circumstances deemed unsuitable for enrollment by the investigator;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Epinephrine;Inflammatory factor IL-17;Resting and exercise pain scores at 72h postoperative (T9); | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamics;First postoperative time for salvage analgesia;Patient operation time, anesthesia time, awakening time;Total sufentanil and remifentanil during surgery; | — |
Countries
China
Contacts
Public ContactJun Zhang
The Second People's Hospital of Hefei
Outcome results
None listed